BcMag™ Alkyne-Activated Magnetic Beads are uniform inert silica-based magnetic beads grafted with a high density of alkyne functional groups on the surface (Fig.1). The beads are specifically designed to efficiently enrich azide-tagged biomolecules from complex cell lysates via a Cu(I)-catalyzed Alkyne-Azide (CUAAC) reaction. Compared with other affinity resins such as agarose or other polymers beads, the inert silica enclosed magnetic beads offer high stability, low nonspecific binding, and superior handling in protein-based systems. These magnetic beads are ideal tools for genomics, proteomics, biomarker discovery, posttranslational modification (PTM) analysis, etc.

Workflow

The beads work perfectly as affinity resin for capturing azide-tagged biomolecules from complex cell lysate. Add the beads to a sample containing the tagged biomolecules, then mix, incubate, wash and elute the target molecules.

Features and Advantages

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Easy to use

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Stable covalent bond with minimal ligand leakage

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Produces reusable matrices

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Low nonspecific binding

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Instruction Manual

MSDS